Zhou Jin, Guangfa Wang
European Respiratory Journal 2024 63: 2400142; DOI: 10.1183/13993003.00142-2024 

Extract

We read with interest the paper by Higbee et al. [1] that was recently published in the European Respiratory Journal. They discovered 22 single nucleotide polymorphisms (SNPs) associated with preserved ratio impaired spirometry (PRISm) through a two-stage sample population, four of which were associated with lung function, highlighting the usefulness of performing genome-wide association study (GWAS) of different lung function traits and phenotypes to maximise discovery of heritable genetic variants of lung function and disease, and that genetic risk factors for PRISm overlap with those for other lung diseases and extrapulmonary comorbidities. These findings have significant clinical implications. While this study's rigorous efforts and important contributions are greatly appreciated, some beneficial suggestions for future development are provided.