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Evaluation of spirometry test as monitoring tool in lung cancer patients
PDPI Lampung & Bengkulu, 15 Sep 2017 15:09:27
Evaluation of spirometry test as monitoring tool in lung cancer patients

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Deepak Aggarwal1, Varinder Saini1 and Ashok Janmeja1
1Pulmonary Medicine, Govt Medical College & Hospital, Chandigarh, India

Introduction: Response to chemotherapy in advance lung cancer is measured by serial contrast enhanced computed tomography (CT) of thorax, using Response Evaluation Criteria in Solid Tumours (RECIST ). However, CT does not tell about functional status of the patient that seems more relevant. Spirometry is a potential monitoring test that has not been tested earlier.

Aims: The present study was planned to evaluate spirometry as a monitoring tool in advanced lung cancer patients on chemotherapy.

Methods: It was a prospective observational study on 40 lung cancer patients. Tumor burden using RECIST criteria and spirometry (FEV1, FVC and FEV1/FVC) were calculated at baseline and after 4 cycles of chemotherapy. Change in spirometry values was compared with CT score for possible association.

Results: Squamous cell carcinoma was the commonest histological type (40%). There was statistically significant improvement in the RECIST score (mean change: -2.48 1.55 cm, 95% confident interval: -3.36 -1.60; P value <0.001) after 4 cycles. However, both FEV1 and FVC marginally decreased (mean change in FEV1 -0.08 0.24 litres; P value 0.06 and mean change in FVC -0.04 0.28 litre; p value 0.39). Baseline RECIST score strongly correlated with the change in RECIST score (correlation coefficient: 0.7, P value <0.001).

Conclusion: Improvement in the tumor burden as measured by serial CT does not reciprocate into improvement in lung function.

Source : http://erj.ersjournals.com/content/48/suppl_60/PA2815
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