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The impact of depression and anxiety on never-smokers COPD patients
PDPI Sulawesi Selatan & Utara, 26 Sep 2017 15:01:00
The impact of depression and anxiety on never-smokers COPD patients

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Rebeca Sicilia Torres1, C. Cabrera1, C. Casanova1, F. León1, G. Juliá1, J. Marín1, P. De Torres1, M.A. García1, M. Divo1 and B. Celli1
1Pneumology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain, 2Pneumology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain, 3Pneumology, Hospital Universitario Virgen de la Candelaria, Santa Cruz de Tenerife, Spain, 4Pneumology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain, 5Pneumology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain, 6Pneumology, Hospital Universitario Miguel Servet, Zaragoza, Spain, 7Pneumology, Clínica Universitaria de Navarra, Navarra, Spain, 8Statistics, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain, 9Pulmonary and Critical Care Division, Brigham and Women's Hospital, Boston, United States, 10Pulmonary and Critical Care Division, Brigham and Women's Hospital, Boston, United States


Introduction Little is known about anxiety and depression and their impact among never-smokers COPD patients. The aim of our study was to assess the prevalence of these disorders and their effect on the quality of life and clinical parameters.

Methods We carried out a cross-sectional study in two terciary hospitals. The presence of anxiety and depression was assessed using the Hospital Anxiety and Depression (HAD) scale. The COPD Assessment Test (CAT) was used to evaluate quality of life. The BODE and COTE (COPD specific comorbidity test) indexes were also calculated. The clinical parameters included were dyspnea measured by the modified Medical Research Council scale (mMRC), six minutes walking test (6MWT), exacerbations and body mass index (BMI).

Results We enrolled 260 patients, 180 smokers and 80 never-smokers. There were no significant differences in age, gender, forced expiratory volumen in one second (FEV1%) and dyspnea (mMRC).

The prevalence of anxiety (A) and depression (D) was higher in smokers than in never smokers (A: 66.9% vs. 34.6%, p<0.001; D: 30.2% vs. 20.5%, p=0.174), as well as the CAT score (15 vs. 12.6, p=0.70). The presence of anxiety and depression in never-smokers was significantly associated with less distance walked and more dyspnea at the end of the 6MWT, more exacerbations and higher scores in the CAT, BODE and COTE indexes. Only 40% of anxious and depressed never-smoker patients had antidepressant medication.

Conclusions The prevalence of anxiety and depression is lower in never-smokers. These disorders are clearly influenced by clinical parameters in this population.



Source : http://erj.ersjournals.com/content/48/suppl_60/PA547
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