APSR IDI Online KlikPDPI Halaman Admin Forum Umum Facebook Page Twitter Instagram Youtube
Childhood Wheeze - A Risk Factor for COPD?
PDPI Lampung & Bengkulu, 02 Nov 2018 09:20:24


Background: COPD is an important cause of morbidity and mortality worldwide. Although cigarette and biomass smoke are major risk factors, additional factors appear to be important. Studies tracking early-life lung function suggest that children who experience viral associated wheezing should be at risk of COPD as adults, however this needs to be shown.

Aims: To relate categories of wheeze assigned at 10 years of age to COPD and lung function decline in the 6th decade.

Methods: The WHEASE (What Happens Eventually to Asthmatic children: Sociologically and Epidemiologically) cohort was recruited in 1964, participants were randomly selected Aberdeen schoolchildren aged 10-15 years (n=2511), categorised into wheezing phenotypes: childhood asthma (CA), childhood wheezy bronchitis (CWB) and non-wheezing controls. The cohort was reassessed by questionnaire and spirometry in 1989, 1994, 2001 and 2014. COPD was defined as post-bronchodilator FEV1/FVC ratio<0.7.

Results: 330 cohort members took part in WHEASE 2014, mean age 61yrs, 52% male. There were 38 with CA, 53 with CWB and 239 non-childhood wheeze controls. In multivariate cross-sectional analysis CA adults were more likely to have COPD (OR 4.14, 95% CI 1.63-10.53, p=0.003), and CWB had a non-significant increase in COPD (1.33, 0.66-2.66, p=0.426). In multivariate longitudinal analysis of 1989, 1994, 2001 and 2014 data, both CA (8.23, 4.20-16.1) and CWB (1.69, 1.01-2.82) adults were independently more likely to have COPD. No difference across wheeze groups was found in the rate of FEV1 decline in 1989-2014, but CA and CWB groups had reduced FEV1 from the outset.

Conclusions: Childhood wheezing illness appears to be associated with an increased risk of COPD in adult life.

Tutorial Aplikasi ISR
Uploaded on May 11, 2015
World Asthma Day 2018
Uploaded on Apr 30, 2018