APSR IDI Online KlikPDPI
APSR IDI Online KlikPDPI Halaman Admin Forum Umum Facebook Page Twitter Instagram Youtube
Lung Cancer Screening White Paper: a Slippery Step Forward?
PDPI Surakarta, 08 Apr 2019 05:30:53

We have read with great interest the White Paper on lung cancer screening published jointly by the European Respiratory Society and the European Society of Radiology [1]. While it has some thoughtful insights, it also has some misconceptions.

1) Use of evidence. The benefit of lung cancer screening is controversial. Even in the USA, the limits that Medicare put on screening are very substantial in terms of requiring registries and limiting screening centres. There are different recommendations from scientific societies based on the same evidence (age range, ex-smokers inclusion). The American Academy of Family Physicians and others do not even recommend screening [2, 3]. The mortality benefit of lung cancer screening is not 20% but rather 16% (20% lower) according to published data using a longer National Lung Screening Trial (NLST) follow-up [4]. This is an important point that reduces the screening benefit. An extremely relevant limitation of lung cancer screening observed in the NLST is a low downstaging. Downstaging is the core objective of any screening programme as it allows the modification of the clinical course of a disease. The first and second incidence rounds of NLST showed 59% and 64% of stage I lung cancers compared with 54.6% in the prevalence round [5]. Stage I downstaging with lung cancer is below 10%. The authors state that 60-80% of screening-detected cancers will be stage I and this is an overstatement which can lead to misinterpretation [1]. 30% of screen-detected lung cancers in incidence rounds are stages III or IV in the NLST.

2) Overdiagnosis. Overdiagnosis exists and is higher than the 18% observed by Patz et al. [6] when comparing computed tomography (CT) with chest radiography in the NLST. As the White Paper correctly points out, radiography used for lung cancer screening also showed overdiagnosis in other studies [7]. It is logical therefore to think that overdiagnosis is even higher when comparing chest CT with standard practice without screening. Furthermore, overdiagnosis, by definition, biases results towards a better survival. The higher the rate of overdiagnosis in a given screening programme, the higher the benefit achieved (lower mortality and lower adverse effects related to screening).

3) Radiation induced cancers. In our opinion, the White Paper underscores the importance of radiation induced cancers. A person undergoing lung cancer screening would suffer more than 25 low-dose CTs. Considering the number of false positives, even in case of using volumetric criteria to reduce false positives, it is expected that at least one in five incidence screens would be a false positive and therefore need extra image-based work-up. A diagnostic CT uses much more than 2-3 mSv and such screening would occur at least five times in the 25 years of screening. This radiation dose would be higher than that received by atomic bomb survivors or nuclear plant workers (40 mSv) [8].

4) Cost-effectiveness of health interventions. The cost matters, and lung cancer screening which includes diagnostic work-up of large numbers of positive patients is extremely expensive. $81 000 per quality-adjusted life year (QALY) is a high cost [9], and the upper limit of this estimation is $186 000. Cost per QALY for ex-smokers, which comprised 52% of NLST patients, is $615 000. We have to add the cost of implementation of a lung cancer screening programme, which is also very high (purchase of dedicated CTs, dedicated personnel, an information system and so on). The cost per QALY for tobacco cessation interventions ranges between 1000 and 5000 [10]. It is obvious that the savings obtained by quitting smoking are significant. If we consider the cost-opportunity, smoking cessation reduces the risk of many diseases and extends lifespan an average of 10 years [11]. The cost of lung cancer screening might also have important differences depending on the European country applying it. Cost-effectiveness of smoking cessation has to be included in lung cancer screening debate.

It seems too early to promote lung cancer screening in Europe due to the aforementioned reasons. While lung cancer screening was shown as beneficial in only one study, this benefit is not exempt of risks. The downstaging observed is discrete. It is estimated that lung cancer screening might prevent between 6500 and 8000 annual lung cancer deaths in the USA, 5% of the total annual lung cancer deaths [12]. For each 1000 screened individuals, lung cancer deaths will be reduced from 21 to 18 (16%). From different points of view, the impact of screening on lung cancer deaths is very low [13].

Finally, no European study has indicated any benefit related with lung cancer screening and researchers are currently working on a European Lung Cancer pooling study. Recent results of the DANTE (Detection and Screening of Early Lung Cancer with Novel Imaging Technology and Molecular Assays) study do not show any benefit [14], the same as the Danish Lung Cancer Screening Trial [15]. The reason for divergence between European studies and NSLT is currently unknown. It might be due to selection bias in NSLT (younger age or higher education of participants) or the selection of excellent participating centres (low surgical mortality). One last reason, but not less important, is the different health system model used in each geographical area. Is there such strong evidence to promote the introduction of lung cancer screening in Europe? Has its cost-effectiveness been demonstrated compared with cheaper alternatives? Are we in such a hurry that we cannot wait some months for the European Pooling or Nelson study results? With the current evidence, lung cancer screening should be restricted to the individual discussion patient-clinician. In our opinion, the white paper is a slippery step forward that might not be beneficial to European patients and that threatens the economic sustainability of European health services.

MITRA KERJA
VIDEO
Tutorial Aplikasi ISR
Uploaded on May 11, 2015
World Asthma Day 2018
Uploaded on Apr 30, 2018