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Associated Factors to Tuberculosis Transmission
PDPI Sumatera Utara, 12 Apr 2019 21:28:23

Abstract

Aim: To know factors that have influence on the infectiousness of tuberculosis (TB).

Methods: Prospective study of a cohort of contacts of patients with TB (Spanish Register of TB from SEPAR). We studied associated factors of infection and disease, in relation to data from TB index cases and their contacts. Associated factors were based on a logistic mixed model, calculating odds ratios (OR) oand its 95% confidence intervals (CI). Statistical significance was set at alpha<0.05.

Results: In 1839 contacts from 485 index cases, we found 69 secondary TB cases (3.75%) and 729 (39.64%) with latent TB infection (LTBI). Tables show the associated factors for LTBI and TB disease considering variables from index cases and contacts (multivariate analysis).

Table I.

Associated factors for LTBI

OR 95% CI p value
Index case
Smear positive 3.24 1.92-5.47 <0.01
Smear negative, culture + 1.77 0.98-3.21 0.06
Any drug resistance 2.49 1.17-5.33 0.01
Diagnostic delay >52 days 1.56 1.05-2.30 0.02
Contacts
Household 2.14 1.52-2.99 0.04
Negative previous IGRA 8.02 3.28-19.56 <0.01
Table II.

Associated factors for TB Disease.

OR 95% CI p value
Index case
Age 18 to 31 years-old 5.40 1.38-2.12 0.01
Contacts
Contact less than 6 hours daily 0.15 0.03-0.82 0.02
immigrant 0.28 0.11-0.68 <0.01
IGRA + 1.31 2.69-6.40 <0.01
Age 31 to 50 years-old 0.39 0.15-0.99 0.04

Conclusions: In the development of LTBI the microbiological status and the diagnosis delay of the index case and contact being household and negative previous IGRA have influence. In relation to TB disease age of the index case, and contact being IGRA + are associated factors; contacts being immigrant, less time of contact, and age 31-50 years-old have less risk.

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