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Ozone Exposure Leads to Changes in Airway Permeability, Microbiota and Metabolome: a Randomised, Double-Blind, Crossover
PDPI Sulawesi Selatan & Utara, 09 Sep 2020 15:35:21

Extract

The associations between atmospheric ozone pollution and increased risks of respiratory diseases have been well established [1, 2], but the underlying biological mechanisms are not fully ascertained. Lung epithelial cells may be injured by inhaled ozone, but results have not been fully consistent [3, 4]. Furthermore, respiratory microbiota and metabolic homeostasis have been deemed to be key factors in maintaining human respiratory health, and any disturbances in this balance have the potential to increase susceptibility to respiratory infectious diseases [5]. However, few human studies have investigated the potential effects of ozone inhalation on respiratory microbiota and metabolome.

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