weight reduction intervention in children with overweight and asthma
Willeboordse1,6, Kim D.G. van
de Kant1, Frans E.S. Tan2, Sandra Mulkens3, Julia
Schellings4, Yvonne Crijns4, Liesbeth van
de Ploeg5, Onno C.P. van
Schayck6 and Edward
Respiratory Medicine, School for Public Health and Primary Care
(CAPHRI), Maastricht University Medical Centre (MUMC), Maastricht,
2Methodology and Statistics,
CAPHRI, MUMC, Maastricht, Netherlands,?3Clinical Psychological Science,
MUMC, Maastricht, Netherlands,?4Physiotherapy, MUMC, Maastricht,
Netherlands,?5Dietetics, MUMC, Maastricht,
Netherlands,?6Family Medicine, CAPHRI, MUMC,
is increasing evidence that obesity is related to asthma development
and severity. In children, it is largely unknown whether weight
reduction contributes to improvements in asthma outcomes. We
investigated the effects of a multifactorial weight reduction
intervention on body weight and clinical asthma characteristics in
children with asthma and overweight or obesity.
18 month weight reduction RCT was conducted in 87 children with asthma
and overweight or obesity. The intervention consisted of an intense
programme with sport-, lifestyle-, parental- and individual sessions.
Every 6 months, measurements of anthropometry, lung function, lifestyle
parameters and inflammatory markers were assessed.
18 months, BMI-standard deviation score decreased slightly with
-0.12?0.32 (p<0.01). However, this decrease was
equally present in the intervention and control group. Clinical asthma
characteristics (including asthma control, quality of life) and lung
function indices (including forced expiratory volume, expiratory
reserve volume) improved over time, although equally in the
intervention and control group (all parameters p≥0.05). Only
changes in forced vital capacity differed significantly between groups
(p<0.05), with increases in intervention group of
10.1?8.7%, and in control group of 6.1?8.4%.
Inflammatory markers, and most lifestyle parameters (including diet,
step count) did not change over time (p≥0.05), or between groups
intervention demonstrated limited effects on both weight reduction and
lung function. Possible reasons for the low effectiveness are high
attrition rates, low intervention compliance, and weight reduction in
the control group.