Anatomy, Ural State Medical University, Yekaterinburg, Russian Federation
Among the lesions of the
system associated with exposure to aluminum, revealed aluminosis,
developing under the influence of aluminum dust and bauxite
pneumoconiosis, develops mainly in workers of bauxite mines.These are
relatively rare pneumoconiosis.The relationship of lung cancer and
bauxite pneumoconiosis poorly understood.
Identify associated cases of lung cancer and bauxite pneumoconiosis
based on resection material.
The study included 263 cases of lung cancer based on resection
material.Classical methods used to assess lung resectate samples in the
last 5 years.Identified occupational history specially.
Occupational exposure occurred to dust in the 107 cases
(40.7%),including aluminum in 10 cases (3.8%),2 of them had a clinical
diagnosis of pneumoconiosis.Bauxite fibrosis was diagnosed in 6
cases.All patients were males.The median age was
59?7.1years.Smoking history noted in 5 cases,the median
index of pack/years was 2.7.The occupation experience ranged from 19 to
38 years,an average was 30.7?6.7 years.Central lung cancer
was diagnosed in 5 cases,massivetumor in 1 case;non-keratinizing
squamous cell carcinomadetected in 5 cases,small cell cancer - 1
case.Histologically:interstitial fibrosis,dust deposits,
?smoker's macrophages?,the anisotropic crystals of
quartz and fine-grained sediments with glow on polarization microscopy.
These data suggest possible carcinogenic effects of inhaled dust in the
professional environment containing bauxite, and require further