Oksana Omelyanenko-Gonulal1, Leonid
Polovinkin2, Tatyana Rybina1, Elena
Amelchenko1 and Natalya
1Clinical Laboratory of
Occupational Diseases, Republican Scientific and Practical Center of
Hygiene, Minsk, Belarus, 2Toxicology Lab, Republican
Scientific and Practical Center of Hygiene, Minsk, Belarus, 3Microbiology Lab, Republican
Scientific and Practical Center of Hygiene, Minsk, Belarus
Cytokine gene polymorphism could predispose to different susceptibility
to occupational dust exposure.
aimed to assess cytokine gene polymorphism contribution to occupational
lung diseases development and management.
Study included 240 patients (pts) with occupational lung diseases
(pneumoconiosis, occupational chronic bronchitis, occupational COPD),
mean age 56?9 years old. 60 comparable healthy volunteers
with occupational hazards were enrolled. The participants of the study
were genotyped on the candidate genes (TNF-α, EPHX1, CAT,
IL-1, IL-6) by real time PCR technique.
Allele A of TNF-α gene in G(-308)A position: incidence in pts
with occupational lung diseases ? 44,8% (number of
heterozygotes prevailed), incidence in control group ? 24,5%
(wild GG type was more frequent)(χ?=6,49;
p=0,011).Heterozygotes in G (-308)A position are the risk group of the
occupational lung diseases development (sensitivity of the marker
? 89%, specificity -53%, AUC=0,71).
Genotyping of TNF-α gene in G(-308)A locus could be used as a
screening test among the workers with occupational dust exposure to
detect those requiring further surveillance and follow up. This could
be a helpful method to reveal early disease development.