Perhimpunan Dokter Paru Indonesia - Gene polymorphism in occupational lung diseases, development and management
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Gene polymorphism in occupational lung diseases, development and management




Oksana Omelyanenko-Gonulal1, Leonid Polovinkin2, Tatyana Rybina1, Elena Amelchenko1 and Natalya Dudchik3
1Clinical Laboratory of Occupational Diseases, Republican Scientific and Practical Center of Hygiene, Minsk, Belarus, 2Toxicology Lab, Republican Scientific and Practical Center of Hygiene, Minsk, Belarus, 3Microbiology Lab, Republican Scientific and Practical Center of Hygiene, Minsk, Belarus

Background: Cytokine gene polymorphism could predispose to different susceptibility to occupational dust exposure.

Aim:We aimed to assess cytokine gene polymorphism contribution to occupational lung diseases development and management.

Materials and methods: Study included 240 patients (pts) with occupational lung diseases (pneumoconiosis, occupational chronic bronchitis, occupational COPD), mean age 56?9 years old. 60 comparable healthy volunteers with occupational hazards were enrolled. The participants of the study were genotyped on the candidate genes (TNF-α, EPHX1, CAT, IL-1, IL-6) by real time PCR technique.

Results: Allele A of TNF-α gene in G(-308)A position: incidence in pts with occupational lung diseases ? 44,8% (number of heterozygotes prevailed), incidence in control group ? 24,5% (wild GG type was more frequent)(χ?=6,49; p=0,011).Heterozygotes in G (-308)A position are the risk group of the occupational lung diseases development (sensitivity of the marker ? 89%, specificity -53%, AUC=0,71).

Conclusions: Genotyping of TNF-α gene in G(-308)A locus could be used as a screening test among the workers with occupational dust exposure to detect those requiring further surveillance and follow up. This could be a helpful method to reveal early disease development.

http://erj.ersjournals.com/content/42/Suppl_57/P4245



PDPI Surakarta. 13/04/17.



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