Sugimoto Yukihiro1, Yamamoto
Takayuki1,3, Nakazato Mio2 and Takayama
1Respiratory Medicine, Fukuoka Seisyukai
Medicine, Fukuoka Seisyukai Hospital, Fukuoka, Japan, 3Internal Medicine, Self-defense Forces
Fukuoka Hospital, Fukuoka,
Aspiration pneumonia (AP) is a dominant form of community-acquired,
hospital-acquired and nursing and healthcare-associated pneumonia, and
a leading cause of death among ageing populations.However, the risk
factors for fatal outcome in AP with postural drainage (PD) have not
been fully evaluated.
The purpose of the present study was to determine the risk factors for
fatal outcome in AP with PD.
Retrospective study from 04/2014 to 03/2015 of patiens with clinically
and radiologically confirmed AP and were performed PD in our hospital.
We conducted a case-control study using 33 cases with dead and 95 age-
and sex-frequency-matched controls with alive.
total of 128 AP cases with PD were identified. There were 73(57%) male
patients, the mean age was 83?9 years. In the
univariateanalysis, daily oxygen therapy was a significant risk factor
for fatal outcome in AP with PD (odds ratio[OR], 2.81, 95% confidence
interval [CI], 1.17-6.78, P<0.05), WBC of at the end of
antibiotic treatment (OR, 4.04,95% CI, 2.03-8.05, P<0.01) and
CRP (OR, 3.61, 95% CI, 1.58-8.22, P<0.01). In the multiple
logistic regression analysis, the risk factors for fatal outcome
associated with AP with PD after adjustment for age,sex, bmi and
smoking status, were daily oxygen therapy (OR, 6.23, 95% CI, 2.55-15.2,
P<0.01), WBC of at the end of antibiotic treatment (OR, 5.02,
95% CI, 2.30-10.9, P<0.01) and CRP (OR, 3.71,95% CI, 1.56-8.82,
The risk factors for fatal outcomes in AP with PD were clearly daily
oxygen therapy, WBC and CRP of the end of antibiotic therapy. These
results could help improve clinical management for AP with PD.