Perhimpunan Dokter Paru Indonesia - COPD and pneumonia
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COPD and pneumonia




Burcu Arpinar Yigitbas, Sibel Yurt, Baris Seker, Celal Satici and Ayse Filiz Kosar
Chest Diseases, Yedikule Chest Diseases and Chest Surgery Research and Training Hospital, Istanbul, Turkey

Introduction: The role of inhaled corticosteroids in the treatment of chronic obstructive pulmonary disease (COPD) is well known. Even at higher doses, inhaled corticosteroids are believed to have no association with the incidence of lower respiratory infections. However, recent large center studies have reported a rising incidence of pneumonia after the use of inhaled corticosteroids alone or in fix combination. In this study we aimed to investigate the role of inhaled corticosteroid type in COPD patients hospitalized for pneumonia at our hospital.

Results: There were 54 (71%) males and 22 (29%) females. Mean age was 66 (41-93) years. Smoking history was remarkable in 64 (84%) patients who had a median smoking history of 43 pack/year (4-130 p/y). Twelve patients had a positive biomass history. There were 14 (18.4%) grade 0, 17 (22.4%) grade 1, 32 (42.1%) grade 2, 12 (15.8%) grade 3 and 1 (1.3%) grade 4 COPD patients. Mean leucocyte and CRP levels at admission and discharge were 13.8*103mm3, 9.6*103mm3 and 131 mg/L, 24 mg/L respectively. Given inhaled corticosteroids were budesonide and fluticasone. Budesonide was used in 39 (51%), fluticasone in 31 (41%) and interchangeably in 6 (8%) patients.

Discussion: In COPD patients who develop pneumonia during follow up, the choice of inhaled corticosteroids has no significant effect on the development of pneumonia. This study is limited by its smaller sample size and the lack of a control group; however, it can serve as a pilot study for future studies that will enroll larger patient cohorts.

http://erj.ersjournals.com/content/46/suppl_59/PA3660



PDPI Sumatera Utara. 17/05/17.



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