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Perhimpunan Dokter Paru Indonesia - Clinicopathological prognostic factors in operated for pulmonary carcinoid tumor patients
 
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Clinicopathological prognostic factors in operated for pulmonary carcinoid tumor patients




Dora Marinova1, Yanina Slavova2, Plamen Titorenkov3, Dimitar Kostadinov4, Maja Tafradjiiska1, Eluar Goranov5 and Danail Petrov5
1Pneumology, University Hospital for Pulmonary Diseases "St. Sofia", Sofia, Bulgaria, 2Pathology, University Hospital for Pulmonary Diseases "St. Sofia", Sofia, Bulgaria, 3Pneumology, Military Medical Academy, Sofia, Bulgaria,4Bronchology, University Hospital for Pulmonary Diseases "St. Sofia", Sofia, Bulgaria, 5Thoracic Surgery, University Hospital for Pulmonary Diseases "St. Sofia", Sofia, Bulgaria


Aim:to study the prognostic significance of N-status,pTNM stage,EGFR (Epidermal Growth Factor Receptor), mTOR(phosphorilated on Ser2442)(mamalian Target Of Rapamycin) protein expression and p70S6 kinase(phosphorilated on Ser411)expression in operated for pulmonary carcinoid tumor patients.

Material and methods:Surgically resected specimen (men n=35;women n=42, mean age 48.513) from 64typical carcinoid(TC) and 13atypical carcinoid(AtC) patients were studied. The N-status(N0 n=68;N1/2 n=9),pTNM stage(I n=57; II n=13;III n=7) and immunohistochemical expression of EGFR (positive n=16/negative n=61), mTOR(positive n=34/negative n=43) and p70S6(>90% n=61/≤90% n=16)were evaluated.Statistical methods used:Kaplan-Meier,Wilcoxon,Cox regression analyses.

Results:The 5 year survival for TCs was 88% and for AtCs74%.The difference in mean survival time between TCs (125 months) and AtCs (72 months) was not significant(p=0.24).11% of the TCs were in N1/2 status and 15% of the AtCs were in N1/2 status. The 5 year survival for N0 was 89% and for N1/263% (p=0.085).The mean survival time was significantly longer in N0 status(N0-129 months,N1/2-87,p=0.005),in I and II pTNM status(I/II-125 months,III-38,p=0.005),in cases negative forEGFR (negative-128 months,positive-84,p=0.030), and in cases positive for mTOR (p=0.035). The Cox analysis confirmed the prognostic significance of N status(Hazard ratio[HR]5.25;p=0.012),pTNM stage(HR 14.14;p=0.019)and EGFR expression(HR 3.78;p=0.047).

Conclusions:N0-status,pTNM I/II stage, lack of EGFRexpression and positive mTOR expression may represent favorable prognostic factors in pulmonary carcinoid tumors.

http://erj.ersjournals.com/content/44/Suppl_58/P515



PDPI Sulawesi Selatan & Utara. 19/05/17.



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