Isil Irem Budakoglu4
and Bahar Gktrk5
1Pediatric Pulmonology, Gazi University
Medicine Faculty, Ankara,
Pulmonology, Necmettin Erbakan University Meram Medicine Faculty,
Konya, Turkey, 3Pediatric Pulmonology, Erciyes
University Medicine Faculty, Kayseri,
Education, Gazi University Medicine Faculty, Ankara, Turkey, 5Pediatric Allergy and Immunology,
Baskent University Medicine Faculty, Konya, Turkey
Bronchiolitis obliterans (BO) is a rare, chronic lung disease, which
results in fibrosis and irreversible obstruction of small airway. The
most common cause is severe lower respiratory tract infection in
children, named as post infectious bronchiolitis obliterans (PIBO).
However, BO is often undiagnosed or misdiagnosed as other wheezing
syndromes. Asthma and BO both have similar auscultation and spirometric
findings and PIBO patients may be misdiagnosed as asthma. In this study
we aimed to reveal the frequency of PIBO patients who were previously
misdiagnosed as asthma and the delay of PIBO diagnosis in these
Between 2007-2015, 39 PIBO patients were reviewed. Patients' ages, age
of infection, symptoms, symptom duration, clinical and radiological
findings, pulmonary function tests and asthma prediposing factors were
compared between PIBO patients who were previously diagnosed as
patients not previously diagnosed with asthma.
The mean age of diagnose was 4.640.68 year and 18 (46%) of
them were previously misdiagnosed as asthma. The mean age of diagnose,
the mean symptom duration and oxygen need during the infection differed
significantly between the 2 groups of patients (P < 0.05).
Gender, hospitalization and mechanical ventilation duration, pulmonary
function tests and asthma predisposing factors did not differ between
the 2 groups.
PIBO is an uncommon chronic lung disease and the diagnosis requires
strong doubt. Asthma is known as the most common chronic airway disease
in children and may mask and delay the BO diagnosis in patients with
chronic respiratory symptoms. To authors best knowledge, there is no
other study that shows asthma misdiagnosis delay the PIBO diagnosis.
Source : http://erj.ersjournals.com/content/48/suppl_60/PA3141