and Tuula Vasankari3
1Pulmonary Diseases, Heart and Lung
Center, Helsinki University Central Hospital, Helsinki, Finland, 2National Institute for Health and
Wellfare, National Institute for Health and Wellfare, Helsinki, Finland, 3Finnish Lung and Health Association
(FILHA), Finnish Lung and Health Association (FILHA), Helsinki, Finland
Pulmonary tuberculosis (TB) is associated with chronic airway
obstruction and predicts mortality. Yet, little follow-up data exist
concerning the associations between these in long-term.
To evaluate whether there are associations between past TB,
obstruction, and mortality in 30-years? follow-up.
analysed the survey data of 6701 Finns aged 30 or over who participated
in the Mini-Finland Health Survey between 1978 and 1980, underwent
spirometry, and had all the relevant health information collected. Past
TB was defined either as a disease history (TB treated in hospital or
with TB medications) or a scar indicating TB on chest x-ray.
Obstruction was specified with the lower limit of normal (LLN), and
classified for severity by Global initiative for chronic Obstructive
Lung Disease (GOLD) stages 1?4.
Past TB was closely associated with the prevalence of obstruction after
adjustment for smoking history and other potential confounders. The
adjusted odds ratio of obstruction was 2.21 (95% CI
1.52?3.21) in those with a scar recorded by one of the two
radiologists, 2.48 (1.63?3.78) if recorded by both
radiologists, and 4.59 (2.86?7.37) in those with a disease
history, as compared with subjects without TB. Among those with neither
past TB nor obstruction, with past TB only, with obstruction only, and
with both, the adjusted hazard ratios of subsequent mortality were 1.00
(reference), 1.13 (95% CI 1.04?1.23), 1.67
(1.34?2.08), and 1.84 (1.50?2.26), respectively.
Past TB, and even a scar indicating it on chest x-ray, is a strong
determinant of airway obstruction. Past TB and obstruction predict
mortality with an additive pattern
Source : http://erj.ersjournals.com/content/48/suppl_60/PA2736
Image : https://www.hamiltoncountyhealth.org/wp-content/uploads/tuberculosis_needle.jpg