Duyar Agca1 and Onur Aksu
Province Public Health Department, 3rd TB Dispensary, Ankara, Turkey,2Istanbul
Province Public Health Department, Communicable Disease, Tuberculosis
Section, Istanbul, Turkey
In last 10 years, while
(TB) incidence is declining in Turkey, preventive treatment cases are
increasing. Related with national guidelines, analysis of data in the
field is required.
aimed to analyze the causes and results of TB preventive therapy in
Ankara 5th TB Dispensary. 1999-2012 preventive treatment data of this
dispensary evaluated retrospectively; in this period new preventive
therapy proposals were put forward for close contacts and
Turkey, preventive treatment (registration, follow up, completion) is
managed by TB dispensaries. In this study, by analyzing individual
records of cases , we evaluated the causes of beginning
chemoprophylaxis and completion results.
14 years, totally 3796 persons registered for preventive therapy, 2036
(56,9%) of them were close contacts.
1364 (35,9%) tuberculin skin
positive (TST +) children (15 years and younger) were the second
332 (8,7%) patients who
immunosupressive treatment were the third group and 268 (80,7%) of them
were anti TNF drug users.
2016 cases were treated with
and 20 with Rifampisin (either izoniazid resistance of index case or
side effects related with izoniazid)
completion rates of
close contacts 81,2% ; TST (+) children 94,1 %; immunosuppressed
patients 83,4 % and treatment failure rates 11,7% ; 4,2% ; 6,9%
9 cases were diagnosed TB
preventive therapy and 6 cases after completion; 13(86,6%) of them were
Although chemoprophylaxis completion rates were high in general,
results show that we need more collaboration for reducing preventive
treatment failure and new health policies about latent TB infection.
Source : http://erj.ersjournals.com/content/48/suppl_60/PA2744
Image : http://digjamaica.com/blog/wp-content/uploads/2017/03/Tuberculosis-Drugs.jpg