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Perhimpunan Dokter Paru Indonesia - Resting heart rate and exacerbations in COPD patients
 
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Resting heart rate and exacerbations in COPD patients

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image: myheart.net

Ahmad Izuanuddin Ismail1, Aisya Natasya Musa1, Mohd Arif Mohd Zim1, Mohd Ariff Fadzil2, Norhaya Mohd Razali3, Razul Md Nazri Md Kassim4 and Tengku Saifudin Tengku Ismail5
1Respiratory Unit, Faculty of Medicine Universiti Teknologi MARA, Batu Caves, SelangorMalaysia, 2Population Health and Preventive Medicine, Faculty of Medicine Universiti Teknologi MARA, Sungai Buloh, SelangorMalaysia, 3Respiratory Department, Hospital Sultanah Nur Zahirah, Kuala Terengganu, Malaysia, 4Respiratory Department, Hospital Sultanah Bahiyah, Alor Setar, Malaysia, 5Respiratory Unit, KPJ Tawakkal Specialist Hospital, Kuala Lumpur, Malaysia



Resting heart rate is a readily available data and has been shown to be associated with mortality in COPD. However, there is lack of data on its association with exacerbation.

This is a multi-centre cohort study, 12-month follow up of patients recruited during acute exacerbation of COPD requiring hospitalisation from April 2012 till September 2015. Patient's sociodemographic data, anthropometric indices and medications history were recorded at recruitment. Subjects were followed up in clinic at 3-month after the recruitment (Month-0). The resting heart rate, spirometry and CAT score were collected at baseline. Subsequently, patient was seen at Month-6 and Month-12 and followed up in between via telephone interview to collect data on exacerbation history.

147 patients were recruited with mean age of 66.76 ? 9.25 year. 76.9% had higher resting heart rate (> 80 bpm) with mean resting heart rate of 86.91 ? 13.01 bpm. Patients with higher resting heart rate had significantly higher proportion of exacerbators compared to those with lower resting heart rate at month-3 (54.4% vs. 26.9%, p=0.013). The trend was followed through until Month-9. There were statistically significant moderate strength linear correlation between resting heart rate and exacerbation frequency at month-3, month-6 and month-9 (r = 0.400, p < 0.001; r = 0.440, p < 0.001; and r = 0.416, p = 0.004). The mean exacerbation frequency was also significantly higher in the higher resting heart rate group at month-3 and month-6 (2.00 vs. 0.48, p<0.001; and 3.42 vs. 1.14, p = 0.004).

Patients with higher resting heart rate following exacerbation demonstrated increased risk of exacerbation, with higher exacerbation frequency seen during 3, 6 and 9-month follow up.



Source : http://erj.ersjournals.com/content/48/suppl_60/PA3666
Image : https://myheart.net/...


PDPI Sumatera Utara. 14/09/17.



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