Ahmad Izuanuddin Ismail1, Aisya Natasya Musa1,
Mohd Arif Mohd Zim1, Mohd Ariff Fadzil2, Norhaya Mohd Razali3, Razul Md
Nazri Md Kassim4 and Tengku Saifudin Tengku Ismail5
1Respiratory Unit, Faculty of
Medicine Universiti Teknologi MARA, Batu Caves, SelangorMalaysia,
2Population Health and Preventive Medicine, Faculty of Medicine
Universiti Teknologi MARA, Sungai Buloh, SelangorMalaysia, 3Respiratory
Department, Hospital Sultanah Nur Zahirah, Kuala Terengganu, Malaysia,
4Respiratory Department, Hospital Sultanah Bahiyah, Alor Setar,
Malaysia, 5Respiratory Unit, KPJ Tawakkal Specialist Hospital, Kuala
Resting heart rate is a readily available data and has
been shown to be
associated with mortality in COPD. However, there is lack of data on
its association with exacerbation.
This is a multi-centre cohort study, 12-month follow up of patients
recruited during acute exacerbation of COPD requiring hospitalisation
from April 2012 till September 2015. Patient's sociodemographic data,
anthropometric indices and medications history were recorded at
recruitment. Subjects were followed up in clinic at 3-month after the
recruitment (Month-0). The resting heart rate, spirometry and CAT score
were collected at baseline. Subsequently, patient was seen at Month-6
and Month-12 and followed up in between via telephone interview to
collect data on exacerbation history.
147 patients were recruited with mean age of 66.76 ? 9.25
year. 76.9% had higher resting heart rate (> 80 bpm) with mean
resting heart rate of 86.91 ? 13.01 bpm. Patients with
higher resting heart rate had significantly higher proportion of
exacerbators compared to those with lower resting heart rate at month-3
(54.4% vs. 26.9%, p=0.013). The trend was followed through until
Month-9. There were statistically significant moderate strength linear
correlation between resting heart rate and exacerbation frequency at
month-3, month-6 and month-9 (r = 0.400, p < 0.001; r = 0.440, p
< 0.001; and r = 0.416, p = 0.004). The mean exacerbation
frequency was also significantly higher in the higher resting heart
rate group at month-3 and month-6 (2.00 vs. 0.48, p<0.001; and
3.42 vs. 1.14, p = 0.004).
Patients with higher resting heart rate following exacerbation
demonstrated increased risk of exacerbation, with higher exacerbation
frequency seen during 3, 6 and 9-month follow up.
Image : https://myheart.net/...