"
 
Perhimpunan Dokter Paru Indonesia - Treatment by linezolid of lung TB caused by drug resistant mycobacterium (MBT)
 
Link
Free Web Counters
Members
News
Mitra Kerja
Video
Tutorial Aplikasi ISR
Uploaded on May 11, 2015
World Asthma Day 2018
Uploaded on Apr 30, 2018
"
 

 

Treatment by linezolid of lung TB caused by drug resistant mycobacterium (MBT)

penyakit paru
image: ivey.uwo.ca


Mariya Pavlova1, Anna Starshinova1, Irina Chernokhaeva1, Ekaterina Belyaeva1 and Nadezhda Sapozhnikova1
1Department of Phthisiopulmonology, St. Petersburg Scientific Research Institute of Phthisiopulmonology, St. Petersburg, Russian Federation



Objective: To determine efficiency of treatment of XDR-TB with the use of therapy containing linezolid.

Content and methods: in St-Petersburg Research Institute of Phthisiopulmonology from 2013 to 2015, 49 patients with XDR lung TB, from 18 to 60 have been treated. Linezolid was used in 24 patients with XDR-TB during the first 6 months of intensive phase of treatment in the dose - 600 mg per day intravenously, by drop infusion in combination with 5-6 anti TB drugs taking into account range of MBT drug resistance Studied group (group I). Control group -group II(n=25), used 5-6 anti TB drugs without linezolid.We carried out statistical analysis with the use of the program Statistica 6.0. We applied the criterion chi-square(χ2).

Results: in 6 months of therapy symptoms of intoxication were not detected among all patients both in studied and control groups. Negative results of bacterial excretion were registered in I group significantly higher than in II group: 62.5%(14) against 36.0%(9),(p>0.05). Adverse drug reactions were noted with equal frequency in both groups(29.1%(7) vs 32.0%(8). In patients who used linezolid hepatotoxic reactions occurred in 4 of 7 patients, in 3 patients leukopenia, neutropenia, anemia. In control group - hepatotoxic reactions(5 of 8), diarrhea(3 of 8). When symptomatic therapy was applied adverse drug reactions were resolved. Intensive phase of treatment in both groups lasted 8 months.

Conclusion: inclusion of linezolid in combined anti TB therapy resulted in cessation of bacterial excretion in 6 months in twice more frequent cases vs therapy without linezolid. Incidence of adverse drug reactions when linezolid usage was not higher than occurred for standard therapy.




Source : http://erj.ersjournals.com/content/48/suppl_60/PA2683
Image : http://thescienceofacne.com/wp-content/...



PP-PDPI. 20/09/17.




Halaman Siap Cetak  Halaman Siap Cetak

Kirimkan Pada Rekan  Kirimkan Pada Rekan