Tatiana Bilichenko and Marina Raicheva
Epidemiology, Research Institute of Pulmonology, Moscow, Russian
Streptococcus pneumoniae (S. pneumoniae) occupies a
leading place in
the etiology of community-acquired pneumonia (CAP) in the adults.
to study of the clinical and epidemiological features of CAP in men in
The study included 265 men 18-26 years old with CAP (114 vaccinated and
151 non-vaccinated Pneumo 23 (Sanofi Pasteur, France). The survey
included questionnaires, clinical study,blood analysis, microbiological
examination (ME) of sputum, definition of Antigen capsules of S.
pneumoniae in urine using test Binax NOW S. pneumoniae (Alere Inc.,
United States), a study of CRP by quantitative method and the
microflora of the throat using polymerase chain reaction, chest x-rays
Found that CAP risk factors in men were low anthropometric indicators,
diseases of the upper respiratory tract, 1 and more cases of CAP, lack
of vaccination against S. pneumoniae,tobacco smoking. The risk of CAP
in the first 100 days of service among non-vaccinated was 6.96 (95% CI
3.39-14.58; p < 0.001), compared to vaccinated and clinical
manifestations of CAP were more severe. S. pneumoniae in secret from
the throat was in 48.8% of patients. In ME of the sputum from
vaccinated and non-vaccinated most commonly allocated H. influenzae
(24.1 and 20.0%; p > 0.05), Streptococcus spp. (19.0 and 36.0%;
p = 0.48), S. pneumoniae (10.3 and 4.1%; p > 0.05). Test Binax
NOW S. pneumoniae (+) detected at 2.9% vaccinated and 1,4%
non-vaccinated patients with CAP.
Vaccination with Pneumo 23 reduces the incidence of pneumococcal CAP in
patients at risk, severity of the CAP and the period of the recovery.
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