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Monitoring of antimicrobial resistance respiratory strains of streptococcus pneumoniae

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Nelya Bisenova1 and Aigerim Yergalieva2
1Laboratory of Microbiology, National Scientific Medical Research Center, Astana, Kazakhstan, 2Laboratory of Microbiology, National Scientific Medical Research Center, Astana, Kazakhstan

Objectives: Microbiological screening of respiratory infections establishes the possible change of pathogens, as well as their resistance rate. The aim of this study was definition three-year dynamics of resistant strains of Streptococcus pneumoniae, isolated from patients with community-acquired pneumonia (CAP).

Methods: A total of 153 strains isolated from respiratory specimens collected from 106 hospitalized patients diagnosed with CAP at National Scientific Medical Research Center during 2010 2012 were included to the study. The identification of isolates and antibiotics susceptibility testing were performed by VITEK 2 (bioMerieux) automated system.

Results: The study of etiological structure of sputum showed that Streptococcus pneumoniae was the most common pathogen, detection significantly increased from 35.2% in 2010 to 45.0% in 2012 (p<0.05). The results showed a tendency to increase the resistance strains of Streptococcus pneumoniae during this period. The highest increasing percentage of resistance was observed to macrolides: to clarithromycin from 42.8% in 2010 to 60.0% in 2012, to erythtomycin from 40.0% to 51.8%, to azithromycin from 39.4% to 59.0% respectively. Resistance to penicillin increased from 28.0% to 37.0%, to ciprofloxacin from 22.7% to 36.3%. The lowest increasing percentage of resistance of Streptococcus pneumoniae was to ceftriaxone from 9.0% in 2010 to 15.0% in 2012 and to levofloxacin from 13.0% to 20.0% respectively. No resistance was observed to vancomycin. Conclusion: To reduce the resistance of Streptococcus pneumoniae necessary rational use of antibiotics and requires constant microbiological monitoring.

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PDPI Malang. 14/10/17.

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