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Study on drug sensitivity patterns in tuberculosis in tertiary care

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image: vumc.org

Namrata Saxena1, Vikas Agarwal1 and Amita Nene1
1Chest Medicine, Bombay Hospital and Institute of Medical Science, Mumbai, MaharashtraIndia

Introduction: Currently available reports of Multi Drug Resistance(MDR) & Extensively Drug Resistance Tuberculosis(XDR-TB) prevalence are underestimated because drug-susceptibility testing (DST) is incomplete and surveillance data are lacking from many nations.

Aims: To analyze the drug resistance pattern among TB patients in a Tertiary care in Mumbai

Methods: This is a Prospective study done over period of June 2010 to December 2011.Total of 181 patients MTB Culture Positive were included. DST was done by Bactec MGIT 960.The samples were subjected to DST for the following thirteen drugs with the recommended critical concentrations: Isoniazid, Rifampicin, Pyrazinamide(PZA), Ethambutol, Streptomycin, Amikacin, Kanamycin, Capreomycin, Ofloxacin(OFX), Moxifloxacin, Ethionamide, Para-aminosalicylic acid, and Clofazimine(CFZ).

Result: Out of 181 total patients 83(45.8%) were found to be MDR-TB and 10(5.5%) were XDR-TB. Resistance either to any individual drug or in combination with other drugs was highest for Isoniazid (105, 58.01%), followed by Streptomycin (86, 47.51%), Rifampicin (85, 46.96%), Ethambutol (65, 35.91%), Pyrazinamide (62, 34.25%), Ofloxacin (61, 33.7%), Ethionamide (55, 30.39%), Moxifloxacin (46, 25.41%), Para-aminosalicylic acid (18, 9.94%), Kanamycin (11, 6.08%), Amikacin (10, 5.52%), Capreomycin (10, 5.52%). None of the patient showed resistance to CFZConclusion High resistance to OFX may probably be due to inappropriate use of fluoroquinolone as broad-spectrum antibiotics. High resistance to second line drugs may be due to its is widespread and unchecked prescription. No resistance to CFZ could probably be due to very little ability of MTB to develop resistance to CFZ.

Source : http://erj.ersjournals.com/content/48/suppl_60/PA2679
Image : https://www.vumc.org/tb-center/files/...

PP-PDPI. 16/10/17.

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