surgical resection for stage I high-grade neuroendocrine caricinoma of
Eisuke Mochizuki1, Kyohei
Ooishi1, Koichi Miyashita1, Koshiro Ichijyo1, Syunya Furukawa1, Miyuki
Nagaoka1, Syun Matsuura1, Shinichiro Mikura1, Masaru Tsukui1 and Naoki
RATIONALE: Since high-grade neuroendocrine tumors are
progressive, most cases are inoperable when diagnosed. There are few
reports about the prognosis of patients or the course of the disease
Medicine, Fujieda Municipal Hospital, Fujiedashi, ShizuokakenJapan
OBJECTIVES: To clarify the clinical course of the disease after surgery
and factors influencing the prognosis.
METHODS: We retrospectively assessed 27 patients receiving surgery for
small cell carcinoma (22 cases) and large neuroendocrine carcinoma (5
cases) from January 2005 through January 2015 at our hospital.
RESULTS: Patients were all male, with an average age of 70.9 years. Of
the 27 patients, 22 had received postoperative adjuvant chemotherapy.
Median progression-free survival (PFS) and overall survival (OS) were
1.1 and 5.5 years, respectively. Ten patients were recurrence-free. Ten
patients who underwent surgery within 60 days after the diagnosis
demonstrated a better prognosis regarding OS (p<0.01) than those
operated on after 60 days. The size of the tumor, titer of tumor
markers, chemotherapy, smoking history, and age did not influence PFS
CONCLUSIONS: Early surgical resection for high-grade neuroendocrine
carcinoma stage I may lead to a better prgonosis.
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