Viktor Johansson Strandkvist1,2,
Caroline Stridsman1,2, Helena Backman2,3, Jenny R?ding1 and
of Health Sciences, Lule? University of Technology,
Lule?, Sweden, 2The OLIN-studies, Norrbotten County Council,
Lule?, Sweden, 3Public Health and Clinical Medicine,
Ume? University, Ume?, Sweden
disease (HD) and muscle dysfunction contributing to muscle weakness are
common comorbidities among subjects with COPD. However, the
relationship between muscle weakness, measured as hand grip strength
(HGS), and HD in COPD is unclear.
To evaluate the impact of HD on HGS among subjects with and without
Data was collected from the OLIN COPD study, where subjects with COPD
have been invited to annual examinations since 2005 together with age-
and sex-matched referents without COPD. During 2009, 441 subjects with
COPD (post-bronchodilator FEV1/VC<0.70) and 570 without COPD
participated in structured interviews, spirometry and measurements of
Among COPD subjects and non-COPD subjects, both men and women with HD
had significantly lower HGS compared to those without HD (in COPD: men:
42 kg vs. 47 kg, p=0.003; women: 23 kg vs. 26 kg p=0.005 and in
non-COPD: men: 41 kg vs. 48 kg, p<0.001; women: 24 kg vs. 28 kg,
p=0.002). In a linear regression model, HGS was associated with age,
beta coefficient (B) =-0.46 (p<0.001), male sex, B=19.85
(p<0.001), FEV1% predicted, B=0.06 (p=0.007), and HD, B=-1.83
(p=0.052) among COPD-subjects, while among non-COPD-subjects
corresponding beta coefficients were: age, B=-0.51 (p<0.001),
male sex, B=19.63 (p<0.001), HD, B=-1.17 (p=0.713) and FEV1%
predicted B=0.02 (p=0.324). Smoking habits were not significant in
this population-based study hand grip strength was, as expected,
associated with age and sex among both COPD and non-COPD-subjects.
However, among those with COPD may, besides FEV1% predicted, also heart
disease have an impact on hand grip strength.
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