grip strength is associated with fatigue in COPD
Viktor Johansson Strandkvist1,
Anne Lindberg2, Caroline Stridsman1, Agneta Larsson1, Helena Backman2
and Mikael Andersson3
of Health Sciences, Lule? University of Technology,
Lule?, Sweden, 2Department of Public Health and Clinical
Medicine, Ume? University, Ume?, Sweden,
3Department of Neuroscience, Uppsala University, Uppsala, Sweden
Hand grip strength (HGS) and fatigue are both
related to COPD, but the relationship between HGS and fatigue among
subjects with COPD is unknown.
Aim: To evaluate the relationship between HGS and fatigue
among subjects with and without COPD.
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with COPD and age- and sex-matched referents without COPD have been
followed annually since 2005 in the OLIN COPD study. COPD was defined
as post-bronchodilator FEV1/VC<0.70. In 2014, 304 subjects with
and 362 subjects without COPD were clinically examined including
interviews, spirometry, HGS and the FACIT-Fatigue questionnaire (0-52,
lower scores represent increased fatigue, and clinically relevant
fatigue (CRF) a score ≤43). Linear regression with HGS as
outcome was used to estimate adjusted Beta coefficients for CRF.
subjects with COPD those with CRF had lower mean HGS than those without
CRF; in men 38.6 vs 43.1 kg (p=0.001) and in women 21.9 vs 23.7kg
(p=0.051), corresponding to 42.0 vs 44.2 kg (p=0.114) and 23.1 vs 25.1
kg (p=0.069) in non-COPD. Among subjects with COPD, HGS remained
associated with CRF (Beta coefficient (95%CI)) among men -2.658 (-4.612
to -0.703), but not among women -0.924 (-2.557 to 0.708), when adjusted
for age, height and smoking habits. The corresponding coefficients
among subjects without COPD were non-significant: -0.944 (-3.086 to
1.198) among men and -0.961 (-2.767 to 0.845) among women.
this population-based study hand grip strength was associated with
clinically relevant fatigue among subjects with COPD but not among
subjects without COPD, and among men with COPD the association between
hand grip strength and fatigue remained significant also when adjusted
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