Paplinska-Goryca1, Renata Rubinsztajn1, Patrycja Nejman-Gryz1, Tadeusz
Przybyłowski1, Rafał Krenke1 and Ryszarda Chazan1
University of Warsaw, Warsaw, Poland
Chlamydia pneumoniae is an obligatory
human pathogen involved in lower and upper airway infections, including
pneumonia, bronchitis and sinusitis. Asymptomatic C. pneumonia carriage
is also relatively common. The association of C. pneumonia infections
with the COPD course and acute exacerbations is unclear.
The aim of the study was to investigate the association between
serological features of C. pneumoniae infection with systemic
inflammation and clinical features of COPD.
The study included 59 patients with stable COPD (41F, 18M; median age
68.5 years, 49 ex-smokers, 10 active smokers) who had no, or had
>2 acute COPD exacerbations during last year. The level of IgA
and IgG antibody to C. pneumoniae, IL-6, IL-8, resistin, insulin and
acyl ghrelin was measured in serum by ELISA.
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No differences in clinical and functional data were observed between
COPD patients with normal and elevated level of anti C. pneumoniae IgA
level. The level of anti C. pneumoniae IgA significantly correlated
with IL-8 (r=0.44), IL-6 (r=0.5) and resistin (r=0.42) serum level in
patients with frequent exacerbations only. IgG level correlated
negatively with acetyl ghrelin (r=-0.36) and BMI (r=-0.35) in COPD
patients without frequent exacerbations. This was in contrast to
frequent COPD exacerbation group where significant correlations between
IgG and BMI was demonstrated (r=0.49).
Infections caused by C. pneumoniae do not significantly affect the
clincal course of COPD. Chronic C. pneumoniae infection is associated
with systemic inflammation in patients with more freaquent COPD