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Perhimpunan Dokter Paru Indonesia - The association between Chlamydia pneumoniae chronic infection and inflammation in COPD patients
 
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The association between Chlamydia pneumoniae chronic infection and inflammation in COPD patients

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Magdalena Paplinska-Goryca1, Renata Rubinsztajn1, Patrycja Nejman-Gryz1, Tadeusz Przybyłowski1, Rafał Krenke1 and Ryszarda Chazan1
1Medical University of Warsaw, Warsaw, Poland


Chlamydia pneumoniae is an obligatory human pathogen involved in lower and upper airway infections, including pneumonia, bronchitis and sinusitis. Asymptomatic C. pneumonia carriage is also relatively common. The association of C. pneumonia infections with the COPD course and acute exacerbations is unclear.

The aim of the study was to investigate the association between serological features of C. pneumoniae infection with systemic inflammation and clinical features of COPD.

The study included 59 patients with stable COPD (41F, 18M; median age 68.5 years, 49 ex-smokers, 10 active smokers) who had no, or had >2 acute COPD exacerbations during last year. The level of IgA and IgG antibody to C. pneumoniae, IL-6, IL-8, resistin, insulin and acyl ghrelin was measured in serum by ELISA.

Read More : Risk factors for mortality in severe pneumonia patients followed in ICU

No differences in clinical and functional data were observed between COPD patients with normal and elevated level of anti C. pneumoniae IgA level. The level of anti C. pneumoniae IgA significantly correlated with IL-8 (r=0.44), IL-6 (r=0.5) and resistin (r=0.42) serum level in patients with frequent exacerbations only. IgG level correlated negatively with acetyl ghrelin (r=-0.36) and BMI (r=-0.35) in COPD patients without frequent exacerbations. This was in contrast to frequent COPD exacerbation group where significant correlations between IgG and BMI was demonstrated (r=0.49).

Infections caused by C. pneumoniae do not significantly affect the clincal course of COPD. Chronic C. pneumoniae infection is associated with systemic inflammation in patients with more freaquent COPD exacebrations only.


Source : http://erj.ersjournals.com/content/42/Suppl_57/P4522
Image : http://lcfamerica.org/wp-content/...



PDPI Sumatera Utara. 19/01/18.




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