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Side effects of chemical preparations in patients with drug-resistant pulmonary tuberculosis

Igor Medvinskiy1, Yuriy Chugaev1,2, Sergey Skornyakov2,3 and Natalya Kamaeva1,2
1Science and Research Department, Ural Research Institute for Phtisiopulmonology, Yekaterinburg, Russian Federation, 2Department of Phthiziatry and Pulmonology, Ural State Medical University, Yekaterinburg, Russian Federation, 3Director, Ural Research Institute for Phtisiopulmonology, Yekaterinburg, Russian Federation

 

Background: Out of 12392 children born by HIV-infected mothers 779 (6,3%) were prenatally infected. We have studied therapeutic and clinical epidemiologic characteristics of 28 HIV-infected children with tuberculosis.

Aim: to show high susceptibility of HIV-infected children of tender and preschool age to tuberculosis and fast development of HIV-infection in cases of prenatal contamination.

Materials and methods: Diagnostics of 779 children prenatally infected with HIV was proved during first months of life of these children by findings in blood serum of antibodies to HIV (by ELISA) and virus RNA (by PCR) and by immune blotting. Tuberculosis in 28 children was proved by clinical, laboratory and roentenological (CT) technologies as well as by allergy skin tests with tuberculosis antigens.


Read More : The causes of death among patients with tuberculosis


Results:
Sourses of tuberculosis infection were defined in 67,9% of cases, notably in 80% of cases they appeared to be parents of the infected children.

Tuberculosis of intrathoracic lymphonodus was diagnosed in 19 children (67,9%), primary tuberculosis complex – in 6 children (2,1%). Generalized tuberculosis was diagnosed in 1 child, generalized BCG-infection – in 1 child. In 60% of children clinical course of tuberculosis was complicated by: lung dissemination, bronchopulmonary lesion, destruction of lung tissue. All children were clinically cured from tuberculosis.

Conclusion: HIV-infection in prenatally infected children without treatment reaches the AIDS stage within the 1st year of life (CD4 reduction to 50 cells/mcl and less). However tuberculosis is responsive to treatment even in cases of pronounced immunodeficiency if antiviral and antituberculosis therapy is administered.



Sumber : http://erj.ersjournals.com/content/46/suppl_59/PA703



PDPI Lampung & Bengkulu. 30/01/18.




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