Prognosis of allergic and non-allergic asthma
Some studies indicate that atopy is less important as a predictor of severe asthma. But, remission is more uncommon in allergic asthma than in non-allergic asthma. The purpose of this study was to investigate the prognosis of asthma and risk factors for asthma onset, especially sensitization of specific allergens. A cohort of three age groups responded to a respiratory questionnaire in 1990 and 2003. At baseline, 2060 subjects who reported respiratory symptoms and 482 controls were investigated with interviews, spirometry and skin prick test. A total of 721 asthmatics and 976 subjects without respiratory disease were clinically verified. At follow-up in 2003, 340 subjects with persistent asthma and 186 subjects with asthma remission were identified while 76 subjects reported new asthma onset. Sensitisation to pets and a high symptom score were significant determinants of persistent asthma (ORs 3.23 [95% CI 1.9-5.67], and 5.76 [2.35-13.34] respectively), and onset of asthma, (ORs 2.65 [1.13-4.86.0], and 1.7 [1.21-2.35], respectively).
Anna Rask-Andersen1, Monica Uddenfeldt1, Erik Lampa1 and Christer Janson2