Impact of Diabetes Mellitus on Drug-Resistant Tuberculosis Treatment Outcomes in Georgia
Background. Diabetes mellitus (DM) is associated with an increased risk of tuberculosis (TB). There is growing evidence that this comorbidity might affect TB-disease presentation and treatment response.
Aims and objectives. We investigated the level of impact of diabetes mellitus on drug-resistant tuberculosis (DR-TB) treatment outcomes in condition of adequate management of both diseases.
Methods. Cohort study was provided among 1154 drug-resistant tuberculosis patients integrated in DOTS+ programme in 2009-2010 years in Georgia. Every patient was routinely investigated for DM. To compare the treatment outcomes of patients with and those without diabetes comorbidity dispersive analysis using Kruskal-Wallis - H criteria was provided.
Conclusions. We found no significant difference in proportion of successful treatment outcomes, though default rate was rather higher in patients with diabetes than non-diabetes in the setting of adequate treatment options and management in Georgia.
Marina Kikvidze1 and Lali Mikiashvili1