Namrata Saxena1, Vikas Agarwal1 and Amita Nene1
Bombay Hospital and Institute of Medical Science, Mumbai,
Currently available reports of Multi Drug Resistance(MDR) &
Extensively Drug Resistance Tuberculosis(XDR-TB) prevalence are
underestimated because drug-susceptibility testing (DST) is incomplete
and surveillance data are lacking from many nations.
analyze the drug resistance pattern among TB patients in a Tertiary
care in Mumbai
This is a Prospective study done over period of June 2010 to December
2011.Total of 181 patients MTB Culture Positive were included. DST was
done by Bactec MGIT 960.The samples were subjected to DST for the
following thirteen drugs with the recommended critical concentrations:
Isoniazid, Rifampicin, Pyrazinamide(PZA), Ethambutol, Streptomycin,
Amikacin, Kanamycin, Capreomycin, Ofloxacin(OFX), Moxifloxacin,
Ethionamide, Para-aminosalicylic acid, and Clofazimine(CFZ).
Out of 181 total patients 83(45.8%) were found to be MDR-TB and
10(5.5%) were XDR-TB. Resistance either to any individual drug or in
combination with other drugs was highest for Isoniazid (105, 58.01%),
followed by Streptomycin (86, 47.51%), Rifampicin (85, 46.96%),
Ethambutol (65, 35.91%), Pyrazinamide (62, 34.25%), Ofloxacin (61,
33.7%), Ethionamide (55, 30.39%), Moxifloxacin (46, 25.41%),
Para-aminosalicylic acid (18, 9.94%), Kanamycin (11, 6.08%), Amikacin
(10, 5.52%), Capreomycin (10, 5.52%). None of the patient showed
resistance to CFZConclusion High resistance to OFX may probably be due
to inappropriate use of fluoroquinolone as broad-spectrum antibiotics.
High resistance to second line drugs may be due to its is widespread
and unchecked prescription. No resistance to CFZ could probably be due
to very little ability of MTB to develop resistance to CFZ.
Image : https://www.vumc.org/tb-center/files/...