Naoto Watanabe1 and Sohei Makino1
Allergy and Respiratory, Disease Research Institute, Tokyo, Japan
Aim: We aimed to
determine whether or not switching inhaled medication from twice a day
to once a day would improve adherence and symptoms in patients with
Forty one patients (average age 48.7 years; 22 males, 19 females) with
bronchial asthma who were prescribed with twice-daily combination drugs
of inhaled corticosteroid (ICS)/long-acting beta-2 agonist (LABA)
twice-daily regimen was changed to a regimen comprising once-daily
inhalation of fluticasone furoate (FF)/vilanterol (VI), and the effects
were evaluated using the Adherence Starts with Knowledge-20 (ASK-20)
and a questionnaire survey of FF/VI.
Among the 41 patients, 54% and 46% of them felt that the switch
improved or did not change their symptoms, respectively.
One patient described palpitations as a side effect, and 30 (73%)
patients responded that FF/VI was easy to inhale but 3 (7%) patients
felt it was difficult to inhale.
Twenty one (51%), 2 (5%) and 8 (44%) patients inhaled the medication
during the morning, midday and night, respectively.
The rate of patients who sometimes forgot to use their medication fell
to 17% according to scores of ≥ 4 points in response to question
1 of the ASK-20.
Twenty four (80%) and 5 (17%) of 30 patients who scored ≥ 4
points in question 13 inhaled the same amount and more medication as
before, respectively. The symptoms of 16 (53%) patients concurrently
improved with better adherence.
Switching from ICS/LABA to FF/VI improved symptoms and adherence in
about 50% of the patients.
Medication taken once a day can improve adherence in patients with
bronchial asthma who feel that inhaling medication twice a day is
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