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Increasing physical activity in severe asthma: a systematic review and meta-analysis
PDPI Sumatera Utara, 01 Ags 2022 07:39:30


Introduction/Aim Physical inactivity is common in asthma and is recognised as an important modifiable risk for poor clinical outcomes such as impaired asthma control and health-related quality of life (HRQoL). Despite evidence supporting the role of physical activity (PA) in reducing the risk of these outcomes, little is known about optimal interventions for increasing PA in those with severe disease. This systematic review and meta-analysis evaluates the effectiveness of interventions in increasing PA in severe asthma.

Methods Medline, CINAHL, EMBASE, PubMed, Informit, SPORTDiscus and Cochrane databases were searched up to September 2021 for PA-based intervention studies that assessed PA outcomes (e.g. steps·day−1, time spent undertaking PA) in adults with severe asthma. Data on asthma-related (e.g. asthma control) and health-related outcomes (e.g. HRQoL) were assessed as secondary outcomes. The Revised Cochrane ROB tool was used to assess risk of bias. Random-effects meta-analyses synthesised data where possible. PROSPERO ID: CRD42021210968

Results Four RCTs (all 12-weeks in duration) including 176 adults with moderate-to-severe asthma were included. An increase in PA was reported with a moderate-vigorous intensity aerobic and resistance training intervention (steps·day−1 and time spent undertaking PA), and an unsupervised pedometer-based intervention (steps·day−1). Meta-analyses showed that PA interventions had an overall positive effect on steps·day−1 (MD=1588, 95% CI:399, 2778; p=0.009, I2=23), asthma control (MD=-0.65, 95% CI: −0.95, −0.35; p<0.0001, I2=0%), and HRQoL (MD=0.56, 95% CI:0.10,1.01; p=0.02, I2=16%) compared to control.

Conclusion While there is some evidence supporting the effectiveness of interventions in improving PA in adults with severe asthma, higher-quality, large-scale studies of longer duration are needed to determine the optimal intervention.

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