Catherine Riou, Elsa du Bruyn, Grace Hyun J. Kim, Irene da Costa, Jihey Lee, Alan Sher, Robert J. Wilkinson, Brian W. Allwood, Jonathan Goldin

European Respiratory Journal 2023 62: 2300600; DOI: 10.1183/13993003.00600-2023

Extract

Efforts to curb the tuberculosis (TB) pandemic remain hindered by a lack of objective measures to quantify disease severity and track treatment success that are valid in both HIV-1-infected and -uninfected TB patients. Ralph et al. [1] developed a promising radiographic scoring system, with baseline scores being predictive of sputum smear conversion at 2 months, but it is reliant on skilled readers and has not been systematically validated in predominantly HIV-infected study populations with varying CD4 counts. Superior to conventional chest radiography, high-resolution computed tomography (HRCT) is a highly sensitive tool to track endobronchial TB disease extent [2].