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Derivation of a high-resolution CT-based, semi-automated radiographic score in tuberculosis and its relationship to baci
PDPI Sumatera Utara, 28 Sep 2023 06:29:41

Catherine Riou, Elsa du Bruyn, Grace Hyun J. Kim, Irene da Costa, Jihey Lee, Alan Sher, Robert J. Wilkinson, Brian W. Allwood, Jonathan Goldin

European Respiratory Journal 2023 62: 2300600; DOI: 10.1183/13993003.00600-2023


Efforts to curb the tuberculosis (TB) pandemic remain hindered by a lack of objective measures to quantify disease severity and track treatment success that are valid in both HIV-1-infected and -uninfected TB patients. Ralph et al. [1] developed a promising radiographic scoring system, with baseline scores being predictive of sputum smear conversion at 2 months, but it is reliant on skilled readers and has not been systematically validated in predominantly HIV-infected study populations with varying CD4 counts. Superior to conventional chest radiography, high-resolution computed tomography (HRCT) is a highly sensitive tool to track endobronchial TB disease extent [2].

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